Dr. Martin Behne
Department
of Dermatology and Venerology
University Hospital Hamburg-Eppendorf
Martinistraße 52
20246 Hamburg
Germany
m.behne@uke.de
Research
focus
-
Epidermal Ca++ and H+ gradients, their generation, function, and effects in epidermal differentiation, homeostasis, aging, and disease. Ion transporters, and related proteins and structures involved in generation and maintenance of such gradients
-
Advanced microscopy to visualize and measure ionic gradients and epidermal structures
Important publications
-
Behne MJ, Barry NP, Hanson KM, Aronchik I, Clegg RW, Gratton E, Feingold K, Holleran WM, Elias PM, and Mauro TM. Neonatal Development of the Stratum corneum pH gradient: Localization and Mechanisms Leading to Emergence of Optimal Barrier Function. J. Invest. Dermatol., 120:998-1006, 2003
-
Behne MJ, Meyer J, Hanson KM, Barry NP, Crumrine D, Lee JD, Murata S, Clegg RW, Gratton E, Holleran WM, Elias PM, and Mauro T. The sodium/hydrogen antiporter, NHE1, regulates acidification of mammalian epidermis: Role of NHE1 in the regulation of permeability barrier function. J. Biol. Chem., 277:47399-47406, 2002
-
Hanson KM, Behne MJ, Barry NP, Mauro TM, Gratton E, and Clegg RM. Two-Photon Fluorescence Lifetime Imaging of the Skin Stratum Corneum pH Gradient. Biophys. J. 83:1682-1690, 2002
-
Behne M, Uchida Y, Seki T, Ortiz de Montellano P, Elias PM, and Holleran WM. Omega-hydroxy ceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. J. Invest. Dermatol. 114:185-192, 2000