Dr. James Birchall

Welsh School of Pharmacy
Cardiff University
King Edward VII Avenue
Cardiff, CF10 3XF
UK
BirchallJC@Cardiff.ac.uk

Research focus

• Microfabricated microneedles for drug, vaccine and gene delivery to skin
  
  
• Analysis of gene expression in skin
  
  
• Epidermal targeting

Important publications

• Pearton M, Allender C, Brain K Anstey A, Gateley C, Wilke N, Morrissey A and Birchall JC. Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations. Pharm. Res. 2007 Aug 2; [Epub ahead of print]
  
  
• Collins E, Birchall JC, Williams JL and Gumbleton M. Nuclear localisation and pDNA condensation in non-viral gene delivery. J. Gene Med. 9 (2007) 265-274
  
  
• Birchall JC. Stratum corneum bi-passed or removed. In Enhancement in Drug Delivery (Ed. Barry B & Touitou E), CRC Press, Florida, USA (2006) 337-352. (PI) Birchall JC. Stratum corneum bi-passed or removed. In Enhancement in Drug Delivery (Ed. Barry B & Touitou E), CRC Press, Florida, USA (2006) 337-352. (PI)
  
  
• Birchall J, Coulman C, Anstey A, Gateley C, Sweetland H, Gershonowitz A, Neville L, and Levin G. Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by Radio Frequency ablation. Int. J. Pharm. 312 (2006) 15-23
  
  
• Coulman SA, Barrow D, Anstey A, Gateley C, Morrissey A, Willke N, Allender C, Brain K, and Birchall JC. Minimally invasive delivery of macromolecules and plasmid DNA via microneedles. Curr. Drug Deliv. 1 (2006) 65-75
  
  
• Coulman SA, Allender CJ and Birchall JC. Microneedles and other physical methods for overcoming the stratum corneum barrier for cutaneous gene therapy. Crit. Rev. Ther. Drug Carrier Syst. 23 (2006) 1-54
  
  
  
• Birchall JC. Microneedle array technology: the time is right but is the science ready? Expert Rev. Med. Devices 3 (2006) 1-4
  
  
• Birchall J, Coulman S, Pearton M, Allender C, Brain K, Anstey A, Gateley C, Willke N, and Morrissey A. Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles. J. Drug Targeting. 13:415-421, 2005
  
  
• Morrissey A, Wilke N, Coulman SA, Pearton M, Anstey A, Gateley C, Allender C, Brain K and Birchall JC. Determination of mechanical properties of silicon and polymer microneedles. IFMBE Proc. 11 (1) (2005) ISSN 1727-1983
  
  
• Chabri F, Bouris K, Jones T, Barrow D, Hann A, Allender C, Brain K, and Birchall J. Microfabricated silicon microneedles for nonviral cutaneous gene delivery. Br. J. Dermatol. 150:869-877, 2004
  
  
• Birchall JC. Cutaneous Gene Delivery. In: Polymeric Gene Delivery: Principles and Applications (Ed. Amiji MM), CRC Press, Florida, USA, 2004
  

 

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