Prof Dr. Joke A Bouwstra
Department
of Drug Delivery Technology
Leiden/Amsterdam Center for Drug Research
Einsteinweg 55
2300 RA, Leiden
The Netherlands
bouwstra@chem.leidenuniv.nl
Research
focus
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Lipid organisation of stratum corneum: Biophysical and electron microscopic are employed to provide information on the lipid organisation, lipid composition and lipid barrier function
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The effect of surfactants and penetration enhancers on the ultrastructure, lipid organisation in stratum corneum
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Vesicles as delivery systems for drugs and vaccines
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Iontophoresis as tool to modulate transport rate of drugs, in particular dopamine agonists, across the skin
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Optimising culture conditions of a reconstructed skin model
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The use of microneedles to enhance drugs transport across the skin
Important publications
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Grams YY, Whitehead L, Lamers G, Stuurman N, and Bouwstra JA. On-line diffusion profile of a lipophilic model dye in different depth of a hair follicle in human scalp skin. J. Invest. Dermatol. 125:775-782, 2005
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Li GL, de Vries JJ, v/d Steeg TJ, van den Bussche H, Maas HJ, Reeuwijk HJEM, Danhof M, Bouwstra JA, and van Laar T. Transdermal iontophoretic delivery of apomorphine in patients inproved by surfactant formulation pretreatment. J. of Controlled Release 101:199-208, 2005
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Honeywell-Nguyen PL, Groenink HW, de Graaff AM, and Bouwstra JA. The in vivo transport of elastic vesicles into human skin: effcts of occlusion, volume and duration of application. J. Control. Rel. 90:243-255, 2003
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Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, and Ponec M. Structure of the skin barrier and its modulation by vesicular formulations. Progress in Lipid Res. 42:1-36, 2003
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Bouwstra JA, Gooris GS, Cheng K, Weerheim A, Bras W, and Ponec M. Phase behaviour of isolated skin lipids. J. Lip. Res., 37, 999-1011, 1996