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PD
Dr. Johanna M. Brandner
Department
of Dermatology and Venerology
University Hospital Hamburg-Eppendorf
Campus Forschung - Dermatologie
Labor für Zell- und Molekularbiologie
N 27
Martinistraße 52
20246 Hamburg
Germany
brandner@uke.de
Research
focus
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Involvement
of Tight Junctions in barrier function of epidermis and hair follicles
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Extrinsic
and intrinsic influences on (epidermal) wound healing
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Establishment
of ex vivo and in vitro skin models for wound healing, infection,
barrier research and drug testing
Important
publications
- Haass NK*, Ripperger
D*, Wladykowski E, Dawson P, Gimotty PA, Blome C, Fischer F, Schmage
P, Moll I, Brandner JM. Melanoma progression exhibits a significant
impact on connexin expression patterns in the epidermal tumor microenvironment.
Histochem Cell Biol 133:113-24, 2010. 2009 Oct 21.
*shared first-authorship
- Fischer N*,
Brandner JM*, Fuchs F, Moll I, Grundhoff A. Detection of Merkel cell
polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology
and growth phenotype do not reflect presence of the virus. Int J Cancer
126:2133-2142, 2010. Sept 08 [Epub ahead of print]
*shared first-authorship
- Vockel M, Breitenbach
U, Kreienkamp H-J, Brandner JM. Somatostatin regulates tight junction
function and composition in human keratinocytes. Exp Dermatol, accepted
- Pollok S, Pfeiffer
A-C, Lobmann R, Wright CS, Moll I, Martin PEM, Brandner JM. Connexin
43 mimetic peptide Gap27 reveals potential differences in the role
of Cx43 in wound repair between diabetic and non-diabetic cells. Cell
Mol Med, accepted
- Werling AM,
Doerflinger Y, Brandner JM, Fuchs F, Becker JC, Schrama D, Kurzen
H, Goerdt S, Peitsch WK. Homo- and heterotypic cell-cell contacts
in Merkel cells and Merkel cell carcinomas: surprising heterogeneity
and indications for cadherin switching. Histopathol, accepted
- Kirschner N,
Poetzl C, von den Driesch P, Wladykowski E, Moll I, Behne MJ, Brandner
JM. Alteration of tight junction proteins is an early event in psoriasis:
Putative involvement of proinflammatory cytokines. Am J Pathol, 175:1095-106,
2009
- Liew CW*, Vockel
M*, Glassmeier G, Brandner JM, Fernandez-Ballester GJ, Schwarz JR,
Schulz S, Buck F, Serrano L, Richter D, Kreienkamp HJ. Interaction
of the human somatostatin receptor 3 with the multiple PDZ domain
protein MUPP1 enables somatostatin to control permeability of epithelial
tight junctions. FEBS Lett. 583:49-54, 2009
- Eispert AC,
Fuchs F, Brandner JM, Houdek P, Wladykowski E, Moll I. Evidence for
distinct populations of human Merkel cells. Histochem Cell Biol 132:83-93,
2009
- Rickelt S, Franke
WW, Doerflinger Y, Goerdt S, Brandner JM, Peitsch WK. Subtypes of
melanocytes and melanoma cells distinguished by their intercellular
contacts: heterotypic adherens junctions, adhesive associations, and
dispersed Desmoglein 2 glycoproteins. Cell Tissue Res, 334:401-422,
2008
- Ohnemus U, Willers
C, Bubenheim M, Hostkotte, MA, Houdek P, Fischer F, Schmage, P, Moll
I, Brandner JM. An ex-vivo oral mucosa infection model for the evaluation
of the topical activity of antifungal agents. Mycoses, 51:21-29, 2008
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Ohnemus
U, Kohrmeyer K, Houdek P, Rohde H, Wladykwoski E, Vidal S, Horstkotte
MA, Aepfelbacher M, Kirschner N, Behne MJ, Moll I, Brandner JM.
Regulation of epidermal Tight Junctions (TJ) during infection with
exfoliative toxin-negative Staphylococcus strains. J Invest Dermatol,
128:906-916, 2008
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Brandner JM, Zacheja, S, Houdek P, Moll I, Lobmann R. Expression
of matrix metalloproteinases, cytokines and connexins in diabetic
and non-diabetic human keratinocytes before and after transplantation
into an ex-vivo wound healing model. Diabetes Care, 31:114-120,
2008
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Neub
A, Houdek P, Ohnemus U, Moll I, Brandner JM. Biphasic regulation
of AP-1 subunits during human epidermal wound healing. J Invest
Dermatol 127:2453-2462, 2007
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Brandner JM, Kief S, Wladykowski E, Houdek P, Moll I. Tight junction
proteins in the skin. Skin Pharmacol Physiol 19:71-77, 2006
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Haass
NK, Wladykowski E, Kief S, Moll I and Brandner JM. Differential
induction of connexins 26 and 30 in skin tumors and their adjacent
epidermis. J Histochem Cytochem 54:171-182, 2006
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Brandner JM, Houdek P, Hüsing B, Kaiser C and Moll I. Connexins
26, 30 and 43: Differences between spontaneous, chronic and accelerated
human wound healing. J. Invest. Dermatol. 122:1310-1320, 2004
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Meyer
CG, Amedofu GK, Brandner JM, Pohland D, Timmann C and Horstmann
RD. Selection for deafness? Nat. med. 8:1332-1333, 2002
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