Home
 







 








Johanna Brandner (second row second from right) and team

 

PD Dr. Johanna M. Brandner

Department of Dermatology and Venerology
University Hospital Hamburg-Eppendorf
Campus Forschung - Dermatologie
Labor für Zell- und Molekularbiologie
N 27
Martinistraße 52
20246 Hamburg
Germany
brandner@uke.de


Research focus

  • Involvement of Tight Junctions in barrier function of epidermis and hair follicles

  • Extrinsic and intrinsic influences on (epidermal) wound healing

  • Establishment of ex vivo and in vitro skin models for wound healing, infection, barrier research and drug testing




Important publications

  • Haass NK*, Ripperger D*, Wladykowski E, Dawson P, Gimotty PA, Blome C, Fischer F, Schmage P, Moll I, Brandner JM. Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironment. Histochem Cell Biol 133:113-24, 2010. 2009 Oct 21.
    *shared first-authorship

  • Fischer N*, Brandner JM*, Fuchs F, Moll I, Grundhoff A. Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology and growth phenotype do not reflect presence of the virus. Int J Cancer 126:2133-2142, 2010. Sept 08 [Epub ahead of print]
    *shared first-authorship

  • Vockel M, Breitenbach U, Kreienkamp H-J, Brandner JM. Somatostatin regulates tight junction function and composition in human keratinocytes. Exp Dermatol, accepted

  • Pollok S, Pfeiffer A-C, Lobmann R, Wright CS, Moll I, Martin PEM, Brandner JM. Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells. Cell Mol Med, accepted

  • Werling AM, Doerflinger Y, Brandner JM, Fuchs F, Becker JC, Schrama D, Kurzen H, Goerdt S, Peitsch WK. Homo- and heterotypic cell-cell contacts in Merkel cells and Merkel cell carcinomas: surprising heterogeneity and indications for cadherin switching. Histopathol, accepted

  • Kirschner N, Poetzl C, von den Driesch P, Wladykowski E, Moll I, Behne MJ, Brandner JM. Alteration of tight junction proteins is an early event in psoriasis: Putative involvement of proinflammatory cytokines. Am J Pathol, 175:1095-106, 2009

  • Liew CW*, Vockel M*, Glassmeier G, Brandner JM, Fernandez-Ballester GJ, Schwarz JR, Schulz S, Buck F, Serrano L, Richter D, Kreienkamp HJ. Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions. FEBS Lett. 583:49-54, 2009

  • Eispert AC, Fuchs F, Brandner JM, Houdek P, Wladykowski E, Moll I. Evidence for distinct populations of human Merkel cells. Histochem Cell Biol 132:83-93, 2009

  • Rickelt S, Franke WW, Doerflinger Y, Goerdt S, Brandner JM, Peitsch WK. Subtypes of melanocytes and melanoma cells distinguished by their intercellular contacts: heterotypic adherens junctions, adhesive associations, and dispersed Desmoglein 2 glycoproteins. Cell Tissue Res, 334:401-422, 2008

  • Ohnemus U, Willers C, Bubenheim M, Hostkotte, MA, Houdek P, Fischer F, Schmage, P, Moll I, Brandner JM. An ex-vivo oral mucosa infection model for the evaluation of the topical activity of antifungal agents. Mycoses, 51:21-29, 2008

  • Ohnemus U, Kohrmeyer K, Houdek P, Rohde H, Wladykwoski E, Vidal S, Horstkotte MA, Aepfelbacher M, Kirschner N, Behne MJ, Moll I, Brandner JM. Regulation of epidermal Tight Junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains. J Invest Dermatol, 128:906-916, 2008

  • Brandner JM, Zacheja, S, Houdek P, Moll I, Lobmann R. Expression of matrix metalloproteinases, cytokines and connexins in diabetic and non-diabetic human keratinocytes before and after transplantation into an ex-vivo wound healing model. Diabetes Care, 31:114-120, 2008

  • Neub A, Houdek P, Ohnemus U, Moll I, Brandner JM. Biphasic regulation of AP-1 subunits during human epidermal wound healing. J Invest Dermatol 127:2453-2462, 2007

  • Brandner JM, Kief S, Wladykowski E, Houdek P, Moll I. Tight junction proteins in the skin. Skin Pharmacol Physiol 19:71-77, 2006

  • Haass NK, Wladykowski E, Kief S, Moll I and Brandner JM. Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis. J Histochem Cytochem 54:171-182, 2006

  • Brandner JM, Houdek P, Hüsing B, Kaiser C and Moll I. Connexins 26, 30 and 43: Differences between spontaneous, chronic and accelerated human wound healing. J. Invest. Dermatol. 122:1310-1320, 2004

  • Meyer CG, Amedofu GK, Brandner JM, Pohland D, Timmann C and Horstmann RD. Selection for deafness? Nat. med. 8:1332-1333, 2002

 

to the top
© E2BRN - G. Schüring
Impressum