Dr. Ryan F. Donnelly
Lecturer
in Pharmaceutics
School of Pharmacy
Queen's University Belfast
Medical Biology Centre
97 Lisburn Road
Belfast
BT9 7BL
UK
phone: +44 (0) 28 90 972 251
fax: +44 (0) 28 90 247 794
r.donnelly@qub.ac.uk
Research
focus
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Photodynamic therapy
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Microneedle-mediated transdermal and intradermal drug delivery using novel polymeric microneedle arrays
Microneedle-mediated
photosensitiser delivery
Important publications
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Donnelly, R.F., Morrow, D.I.J., McCarron, P.A., Woolfson, A.D., Morrissey, A., Juzenas, P., Juzeniene, A., Iani, V., McCarthy, H.O., Moan, J. (2009). Microneedle Arrays Permit True Intradermal Delivery of a Preformed Photosensitiser. Photochemistry and Photobiology. 85, 195-204
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Donnelly, R.F. McCarron, P.A., Al-Kassas, R., Juzeniene, A., Juzenas, P., Iani, V., Woolfson, A.D., Moan, J. (2009). Influence of Formulation Factors on PpIX Production and Photodynamic Action of Novel ALA-loaded Microparticles. Biopharmaceutics & Drug Disposition. 30, 55-70
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Donnelly, R.F., Morrow, D.I.J., McCarron, P.A., Woolfson, A.D., Morrissey, A., Juzenas, P., Juzeniene, A., Iani, V., McCarthy, H.O., Moan, J. (2008). Microneedle-mediated Intradermal Delivery of 5-Aminolevulinic acid: Potential for Enhanced Topical Photodynamic Therapy. Journal of Controlled Release. 129, 154-162
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Donnelly, R.F., Morrow, D.I.J., Garland, M.J., McCarron, P.A. Woolfson, A.D. (2007). Influence of Solution Viscosity and Injection Protocol on Distribution Patterns of Jet Injectors. Application to Photodynamic Tumour Targeting. Journal of Photochemistry and Photobiology B: Biology. 89, 98-109
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Donnelly, R.F., McCarron, P.A., Cassidy C.M., Elborn, J.S., Tunney, M.M. (2007). Delivery of photosensitisers and light through mucus: Investigations into the potential use of photodynamic therapy for treatment of Pseudomonas aeruginosa cystic fibrosis pulmonary infection. Journal of Controlled Release. 117, 217-226
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Donnelly, R.F., Morrow, D.I.J., McCarron, P.A., Juzenas, P., Woolfson, A.D. (2006). Pharmaceutical Analysis of 5-Aminolevulinic acid in Solution and in Tissues. Journal of Photochemistry and Photobiology B: Biology. 82, 59-71
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Donnelly, R.F., McCarron, P.A., Zawislak, A.A., Woolfson, A.D. (2006). Design and Physicochemical Characterisation of a Bioadhesive Patch for Dose-controlled Topical Delivery of Imiquimod. International Journal of Pharmaceutics. 307, 318-325
- Donnelly, R.F.,
Ma, L.W., Juzenas, P., Iani, V., McCarron, P.A., Woolfson, A.D., Moan,
J. (2006). Topical Bioadhesive Patch Systems Enhance Selectivity of
Protoporphyrin IX Accumulation in Tumours. Photochemistry and Photobiology.
82, 670-675
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Donnelly, R.F., Juzenas, P., McCarron, P.A., Ma, L.W., Woolfson, A.D., Moan, J. (2006). Influence of Formulation Factors on Methyl-ALA-induced Protoporphyrin IX Accumulation in vivo. Photodiagnosis and Photodynamic Therapy. 3, 190-201
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Donnelly, R.F., McCarron, P.A., Lightowler, J.M., Woolfson, A.D. (2005). Bioadhesive Patch-based Delivery of 5-Aminolevulinic acid to the Nail for Photodynamic Therapy of Onychomycosis. Journal of Controlled Release, 103, 381-392
- Donnelly, R.F.,
McCarron, P.A., Woolfson, A.D. (2005). Drug Delivery of Aminolevulinic
acid from Topical Formulations Intended for Photodynamic Therapy.
Photochemistry and Photobiology. 81, 750-767