Dr. Hélène Duplan
Cell
Pharmacology department
Pierre Fabre Research Institute
2, rue Viguerie - B.P. 3071
31025 Toulouse Cedex 3
France
helene.duplan@pierre-fabre.com
Research
focus
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Specific study of cellular processes and molecular targets involved in epidermal terminal differentiation and barrier function; lipids and proteins of the stratum corneum, factors involved in their regulation and trafficking
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Gingival epithelium differentiation and defence
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Establishment of cell and tissue functional models suitable for in vitro investigations of cutaneous pathologies, stresses and homeostasis
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Evaluation of chemicals and vegetal extracts in the fields of inflammation and immunity, photobiology and skin aging, wound healing, skin appendages functions, epidermal defence and homeostasis
Important publications
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Antimicrobial peptide modulation in a differentiated reconstructed gingival epithelium. Cell Tissue Res. 2007 Apr; 328(1) : 85-95.
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Peyret-Lacombe A., Duplan H., Watts M., Charveron M., and Brunel G. Antimicrobial peptide modulation in a differentiated reconstructed gingival epithelium. Cell Tissue Res. (in press) 2006
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Nachat R., Méchin M-C, Charveron M., Serre G., Constans J., and Simon M. Peptidyl deiminase isoforms are differentially expressed in the anagen hair follicules and other human apendages. J. Invest. Dermatol. 125 : 34-41, 2005
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Duplan H. Hydroxydecine is a regulator of oxidative stress and epidermal differentiation : results of in vitro pharmacological studies. IACD - Ducray Symposium, 2005
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Aries M-F., Vaissière C., Pinelli E., Pipy B., and Charveron M. Avena Rhealba® inhibits A23187-stimulated arachidonic acid mobilization, ecosanoid release and cPLA2 expression in human keratinocytes : potential in cutaneous inflammatory disorders. Biological and Pharmaceutical Bulletin 28(4) : 601-6, 2005
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Maury E. , Prevost M-C., Simon M-F., Redoules D., Ceruti I., Tarroux R., Charveron M., Chap H. Identification of two secreted phosplipases A2 in human epidermis. J. Invest. Dermatol. 114 : 960-6, 2000