Dr. Oliver Engelking

CellSystems Biotechnologie Vertrieb GmbH
Langeler Ring 5
53842 Troisdorf
Germany
oliver.engelking@cellsystems.de
www.cellsystems.de

Business focus

• 3D reconstructed human epidermal model EST1000
  - regulatory in vitro toxicity testing (skin corrosion, irritation and phototoxicity)
  - efficacy testing
  - Phototoxicity
  
  
• 3D reconstructed human full thickness model AST2000
  - in vitro toxicity testing (gene toxicity)
  - efficacy testing
  - research (wound healing, immunology etc.)
  
  
• 3D reconstruced dermis equivalent
  
  
• Human primary skin cells from healthy donors + media
  
  
  
• Stem Cells:
  - Keratinocytes stem cells
  - Hair follicle stem cells
  - iP stem cells
  - Cancer Stem Cells (eg. Melanoma stem cells)
  - Cancer Cells (Melanoma, BCC, SCC, etc.)
  
  
• Contract research and testing
  
  

Important publications

• Hoffmann J, Heisler E, Karpinski S, Losse J, Thomas D, Siefken W, Ahr HJ, Vohr HW, Fuchs HW Epidermal-skin-test 1000 (EST-1000)--a new reconstructed epidermis for in vitro skin corrosivity testing. Toxicol In Vitro. 2005 ct;19(7):925-9. Epub 2005 Aug 2
  
  
• J. J. Hoffmann, P. Peters, P. Frost, H. W. Fuchs: Advanced Skin Test 2000 (AST-2000) Reconstructed Human Skin designed for dermatological and Pharmaceutical Research. European Journal of Cell Biology 82, Suppl. 53 (2003) S2-14
  
  
• E. Heisler, J.J. Hoffmann, P. Peters, H.-J. Ahr, H.-W. Vohr: Advanced Skin Test 2000 (AST-2000) as a Potent In Vitro Tool for the Characterization of Skin Reactions by Protein Fingerprinting. Toxicology Letters 144-1 (2003) S44
  
  
• E. Heisler, J. J. Hoffmann, P. Peters, H.-J. Ahr, H.-W. Vohr: Discrimination between local irritancy/cytotoxicity vs. immune reactions in vitro: 3D skin models as helpful tools in immunotoxicology. Immunobiology 206 (2002) 209
  

 

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