Prof. Françoise Falson, PhD

Laboratoire de Pharmacie Galénique Industrielle EA 4169
Faculté de Pharmacie, Université Claude Bernard Lyon1
8 avenue Rockefeller
69373 Lyon
France

phone: +33 4 78 77 71 11
fax:      +33 4 78 77 71 11
falson@univ-lyon1.fr

Research focus

• Epidermal Ca++ and H+ gradients, their generation, function, and effects in epidermal differentiation, homeostasis, aging, and disease. Ion transporters, and related proteins and structures involved in generation and maintenance of such gradients
  
  
• Advanced microscopy to visualize and measure ionic gradients and epidermal structures

Important publications

• F. Veuillez, F. Falson-Rieg, R.H Guy, J. Deshusses and P. Buri. Permeation of a myristoylated di-peptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. Int. J. Pharm., 231,1,1-9, (2000)
  
  
• O. Sorg, C. Tran, P. Carraux, L. Didierjean, F. Falson and J.H. Saurat Oxydative sress-independent depletion of epidermal vitamin A by UVA J.Inv.Derm.,118,3,513-518 (2002)
  
  
• H.L. Boutounne, J.F. Chaulet, C. Ploton, F. Falson, F. Pirot. Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(ε-caprolacton) nanocapsule encapsulated form and as digluconate. J.Controlled Release, 82,319-334, 2002
  
  
  
• F. Pirot, B. Morel, G. Peyrot, T. Vuillet, V. Faivre, C. Bodeau, F. Falson.
  Effects of Osmosis on Water-Holding Capacity of Stratum Corneum and Skin Hydration. Exogenous Dermatology., 2, No 5, 252-257 (2003)
  
  
• H.L. Boutounne, V. Faivre, F. Falson, F. Pirot. Characterization of chlorhexidine loaded nanocapsules transport through hairless and Wistar rat skin.
  Skin Pharmacology and Applied Physiology,17, No. 4 (2004)
  
  
• P.L. Bardonnet, V. Faivre, F. Pirot, P. Boullanger, F. Falson. Cholesteryl oligoethyleneglycol glycosides: fluidising effect of their embedment into phospholipid bilayers, Biochemical and Biophysical Research Communications 329 (4) 1186-1192 (2005)
  
  
• I.D. del Consuelo, Y. Jacques, G.-P. Pizzolato, R. H. Guy, F. Falson. Comparison of the lipid composition of porcine buccal and esophageal permeability barriers. Arch. Oral Biol., 50.12.981-987, (2005)
  
  
  
• F. Pirot, F. Falson, C. Pailler-Mattéi, H.I. Maibach. Stratum corneum: An ideal osmometer. Exog. Dermatol., 3 ,339-349, (2006)
  
  
• N.T.T. Dang, A.-M. Freydiere, H. Constant, F. Falson, F. Pirot. Sustained antibacterial effect of a hand rub gel incorporating chlorhexidine-loaded nanocapsules (Nanochlorex® ). Int. J. Pharm. 334(1-2).166-172, (2006)

 

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