Jean-Pierre
Hachem, M.D., Ph.D.
Professor of Dermatology
Universitair
Ziekenhuis Brussel
Dienst Dermatologie
Laarbeeklan 101
1090 Brussel
Belgium
phone: + 32 2 476 3114
fax: + 32 2 477 6800
jeanpierre.hachem@uzbrussel.be
Research
focus
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Formulation for pharmaceutic and cosmetic applications.
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Percutaneous absorption determination and modulation.
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Buccal absorption determination and modulation.
Important publications
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Hachem JP, Houben E, Uchida Y, Crumrine D, Shurer N, Roelandts T, Choi EH, Brown BE, Feingold KR, Elias. Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis. J Invest Dermatol. 2006 May 11; [Epub ahead of print].
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Hachem JP, Wagberg F, Schmuth M, Crumrine D, Lissens W, Jayakumar A, Houben E, Mauro T, Leonardsson G, Brattsand M, Egelrud T, Roseeuw D, Clayman GL, Feingold KR, Williams ML, Elias PM. Serine Protease Activity and Residual LEKTI Expression Determine Phenotype in Netherton Syndrome. J Invest Dermatol. 2006 Apr 6; [Epub ahead of print].
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Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM. Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity. J Invest Dermatol 2005; 125: 510-20.
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Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C. Parotid secretory protein is an HDL-associated protein with anticandidal activity. Am J Physiol Regul Integr Comp Physiol 2005; 288: R1306-15.
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Hachem JP, Behne M, Aronchik I, Demerjian M, Feingold KR, Elias PM, Mauro TM. Extracellular pH Controls NHE1 Expression in Epidermis and Keratinocytes: Implications for Barrier Repair. J Invest Dermatol 2005; 125: 790-7.