Dr. Marek Haftek, MD, PhD
Directeur
de Recherches CNRS
Laboratoire de Recherche Dermatologique, EA 4169
Pavillon R
Hopital Edouard-Herriot
69437 Lyon
France
haftek@univ-lyon1.fr
Research
focus
-
Role of the molecules of the epidermal intercellular matrix in regulation of the epidermal homeostasis and barrier function
- Epidermal proteoglycans
and their interaction with desmosomes, extracellular lipids, and dendritic
cells: applications in wound healing, skin ageing and atopy
- Pharmacological
regulation of the barrier function
Important publications
-
Haftek M, Simon M and Serre G. Corneodesmosomes : pivotal actors in the stratum corneum cohesion and desquamation. In: " Skin Barrier " (Elias PM, Feingold KR, eds ), Taylor & Francis Group, New York, NY, 2005
-
Norgett EE, Wolf F, Balme B, Leigh IM, Perrot H, Kelsell DP, and Haftek M. Hereditary " white nails ": a genetic and structural study. Br. J. Dermatol. 151:65-72, 2004
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McMillan J, Haftek M, Akiyama M, South AP, McGrath JA, Perrot H, Eady RAJ, and Shimizu H. Alternations in desmosome size and number coincide with the loss of keratinocyte cohesion in skin with homozygous and heterozygous defects in the desmosomal protein plakophilin 1. J Invest Dermatol 121:1-8, 2003
-
Kowalewski C, Schmitt D, Mackiewicz W, Jablonska S, and Haftek M. Expression of cell - cell contact proteins in Darier's Disease and Hailey-Hailey Disease differs from their expression in autoimmune acantholysis. Arch. Dermatol. Res., 293: 1-11, 2001
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Simon M, Jonca N, Guerrin M, Haftek M, Bernard D, Caubet C, Egelrud T, Schmidt R, and Serre G. Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis, and its relationship to desquamation. J. Biol. Chem., 276: 20292-9, 2001 (+ correction in JBC 276: 47742, 2001)