Dr. Edith Hummler
Department
of Pharmacology and Toxicology
University of Lausanne
Rue du Bugnon 27
CH-1005 Lausanne
Switzerland
edith.hummler@unil.ch
Research
focus
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Serine proteases and their implication in skin barrier function
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Role of the epithelial sodium channel (ENaC) in wound healing
- Mouse models for skin diseases
Important publications
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Charles RP, Guitard M, Leyvraz C, Breiden B, Haftek M, Haftek-Terreau Z, Stehle JC, Sandhoff K, and Hummler E. Postnatal requirement of the epithelial sodiumchannel for maintenance of epidermal barrier function. J Biol Chem, 283:2622-2630, 2007
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Porret A, Mérillat AM, Guichard S, Beermann F, and Hummler E. Tissue-specific transgenic and knockout mice. Methods Mol Biol, 337:185-205, 2006
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Oskarsson T, Essers MA, Dubois N, Offner S, Bubey C, Roger C, Metzger D, Chambon P, Hummler E, Beard P, and Trumpp A. Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev, 20:2024-2029, 2006
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Hummler E, and Vallon V. Lessons form mouse mutants of epithelial sodium channel and its regulatory proteins. J Am Soc Nephrol, 16:3160-3166, 2005
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Leyvraz C, Charles RP, Rubera I, Guitard M, Rotman S, Breiden B, Sandhoff K, and Hummler E. The epidermal barrier function is dependent on the serine protease CAP1/Prss8. J Cell Biol, 170:487-496, 2005