Dr. Nathalie Jonca
Group
"Granular keratinocyte and epidermal barrier"
Epidermis Differentiation and Rheumatoid Autoimmunity (UDEAR)
CNRS UMR 5165 - INSERM U1056 - Toulouse III University
CHU Purpan
Place du Dr Baylac - TSA 40031
31059 Toulouse Cedex 9
France
phone: (00) 33 56115 8434
fax: (00) 33 56149 9036
nathalie.jonca@udear.cnrs.fr
Research
focus
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Role of Dermokine β and γ in the late stages of epidermis differentiation
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Corneodesmosin and cohesion of the stratum corneum: involvement in pathophysiology
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Study of the cornified envelope and its component LCE6A
Important publications
- Mazereeuw-Hautier
J, Leclerc EA, Simon M, Serre G, Jonca N.
A novel mutation in CDSN causes peeling skin disease in a patient from Morocco.
Br J Dermatol in press
- Leclerc EA,
Gazeilles L, Serre G, Guerrin M, Jonca N.
The ubiquitous dermokine delta activates Rab5 in the early endocytic pathway.
PloS One, 6:e17816, 2011
- Jonca N, Caubet
C, Leclerc EA, Guerrin M, Simon M, Serre G.
Protease sensitivity of corneodesmosin variants encoded by the six more common CDSN haplotypes.
J Invest Dermatol 131:1381-1384, 2011.
- Leclerc EA,
Huchenq A, Mattiuzzo NR, Metzger D, Chambon P, Ghyselinck N, Serre
G, Jonca N, Guerrin M.
Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction.
J Cell Sci 122:2699-2709, 2009
- Toulza E, Mattiuzzo
N, Galliano M-F, Jonca N, Dossat C, Jacob D, De Daruvar A, Wincker
P, Serre G, Guerrin M.
Large scale identification of human genes implicated in epidermal barrier function.
Genome biology 8:R107:1-23, 2007
- Toulza E, Galliano
M-F, Jonca N, Gallinaro H, Méchin M-C, Ishida-Yamamoto A, Serre
G, Guerrin M.
The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location.
J Invest Dermatol 126:503-506, 2006
- Caubet C, Jonca
N, Brattsand M, Guerrin M, Bernard D, Schmidt R, Egelrud T, Simon
M, Serre G.
Degradation of corneodesmosome components by two kallikreins SCTE/KLK5/hK5 and SCCE/KLK7/hK7.
J Invest Dermatol 122:1235-1244, 2004
- Caubet C, Jonca
N, Lopez F, Estève J-P, Simon M, Serre G.
Homo-oligomerisation of human corneodesmosin is mediated by its N-terminal glycine loop domain.
J Invest Dermatol 122:747-754, 2004
- Levy-Nissenbaum
E, Betz R-C, Frydman M, Simon M, Lahat H, Bakhan T, Goldman B, Bygum
A, Pierick M, Hillmer A-M, Jonca N, Toribio J, Kruse R, Dewald G,
Cichon S, Kubisch C, Guerrin M, Serre G, Nöthen M-M, Pras E.
Hypotrichosis simplex of the scalp is associated with nonsense mutations
in CDSN encoding corneodesmosin.
Nat Genet 34:151-153, 2003
- Jonca N, Guerrin
M, Hadjiolova K, Caubet C, Gallinaro H, Simon M, Serre G. Corneodesmosin,
a component of epidermal corneocyte desmosomes, displays homophilic
adhesive properties.
J Biol Chem 277:5024-5029, 2002