Prof. Dr. Dr. h.c. Reinhard Neubert
Institute
of Pharmacy
Martin Luther University Halle-Wittenberg
Research group Biopharmaceutics / Dermatopharmceutics
Wolfgang-Langenbeck-Straße 4
06120 Halle (Saale)
Germany
reinhard.neubert@pharmazie.uni-halle.de
Research
focus
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Optimisation of drug penetration and -permeation for dermal administration
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Drug formulations: Modern colloidal formulation, such as micro-emulsions and mixed micelles
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Biopharmaceutical analytics: Separation methods such as HPLC and capillary electrophoresis, mass spectrometry (Electrospray, Nano-ESI, APCI, MALDI, LC/MS, CE/MS, GC/MS) and vibrational spectroscopy (Infrared-, near Infrared- and Raman-spectroscopy)
- Characterisation
of the molecular structure of the Stratum corneum lipids using spectroscopic
and calorimetric methods as well as X-ray and neutron scattering;
modifications due to skin diseases such as psoriasis and neurodermatitis
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Development of biosensors and model systems for characterisation of the bio-adhesion using quartz-microbalance
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Studies of the influence of incorporation into colloidal vehicle systems such as mixed micelles and micro-emulsions on the bioavailability and on the pharmacokinetics of highly hydrophilic drugs such as antibiotics which are up to date only parenterally available
- Characterisation
of biologically interesting proteins such as elastin, tropoelastin
and collagen using modern HPLC-MS techniques after digestion of the
proteins
- Non-invasive methods for studying drug penetration FT-IR-ATR- and FT-IR-photoacoustic spectroscopy
ATR diffusion cell for
characterising skin penetration
Important publications
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Bendas, B., Schmalfuß, U., Neubert, R. Influence of propylene glycol as cosolvent on mechanisms of drug transport from hydrogels. Int. J. Pharm. 116, 19-30 (1995)
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Farwanah, H., Neubert, R.H.H., Zellmer, S., und Raith, K. An improved procedure for the separation of major Stratum corneum lipids by means of automated multiple development thin-layer chromatography. J. Chromatogr. B 780, 443-450 (2002)
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Grafe, F., Wohlrab, W., Neubert, R.H.H., Brandsch, M. Transport.of biotin in human keratinocytes. J. Invest. Dermatol. 120, 428-433 (2003)
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Getie, M., Raith, K., Neubert, R.H.H. LC/ESI-MS analysis of two elastin cross links, desmosin and isodesmosin, and their radiation induced degradation products. Biochim. Biophys. Acta 1624, 81-87 (2003)
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Kiselev, M. A., Rybabova, N. Y., Balagurow, A.M., Dante, S., Hauss, T., Zbytovska, J., Wartewig, S., Neubert, R.H.H. New insights into structure and hydration of stratum corneum lipid model membrane by neutron diffraction.
Eur. Biophys. J. 34, 1030-1040 (2005)
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Heuschkel, S., Göbel, A., Neubert, R.H.H. Microemulsions - modern colloidal carrier systems for dermal and transdermal drug delivery.
J. Pharm. Sci. (2007)
www.interscience.wiley.com: DOI 10.1002/jps.20995