Dr. Carien Niessen
Center
for Molecular Medicine (ZMMK)
University of Cologne
LFI, ebene 5, room 059
Joseph-Stelzmannstrasse 9
D-50931 Cologne
Germany
Research
focus
- The role of adherens junctions and polarity proteins in epidermal barrier formation and function
Important publications
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Billion K*, Ibrahim H*, Mauch C, and Niessen CM. Increased soluble E-cadherin in melanoma patients, Skin Pharm. Phys., in press
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Tunggal JA*, Helfrich I, * Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T and Niessen CM. E-cadherin is essential for in vivo skin barrier function by regulating tight junctions. EMBO J. 24:1146-1156, 2005
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Gottardi CJ*, Niessen CM* and Gumbiner BM. The Adherens Junction. Chapter 8. In: Cell Adhesion, ed. by M. Beckerle, The Frontiers in Molecular Biology series, eds. B.D. Hames and Glover, D.M., Oxford University Press, 2002
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Niessen CM and Gumbiner BM. Cadherin mediated cell sorting not determined by adhesion or binding specificity. J. Cell Biol. 156:389-399, 2002
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Yap AS*, Niessen CM* and Gumbiner BM. The juxtamembrane of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol. 141:779-789, 1998
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Niessen CM, Hulsman EHM, Oomen LCJM, Kuikman I and Sonnenberg A. A minimal region on the integrin ?beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J. Cell Sci. 110:1705-1716, 1997
*co-first authors