Assoc. Prof. Dr. Lars Norlén
Department
of Dermatology and Venerology
Karolinska University Hospital
17176 Stockholm
Sweden
and
Medical Nobel Institute, Department of Cell and Molecular Biology
Karolinska Institutet, Nobels v. 3
17177 Stockholm
Sweden
lars.norlen@cmb.ki.se
Research
focus
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Lipid structure of the stratum corneum extracellular space
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Morphogenesis of the stratum corneum extracellular lipid matrix
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Contact dermatitis and atopic dermatitis
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Stratum corneum keratin organization and hydration
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Epidermal keratinisation and dyskeratinization
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Psoriasis and keratodermopathologies
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Lipid protein interaction in the epidermal extracellular space
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Desmosomal differentiation
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Bullous skin disease
Important publications
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Al-Amoudi A, Dubochet J, and Norlén L. Nanostructure of the epidermal extracellular space as observed by cryo-electron microscopy of vitreous sections of human skin. J. Invest. Dermatol. 124: 764-777, 2005
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Norlén L, and Al-Amoudi A. Stratum corneum keratin structure, function, and formation: the cubic rod-packing and membrane templating model. J Invest Dermatol. 123: 715-732, 2004
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Norlén L. Skin barrier formation: the membrane folding model. J. Invest. Dermatol. 117: 823-829, 2001
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Norlén L. Skin barrier structure and function: the single gel-phase model. J. Invest. Dermatol. 117: 830-836, 2001