Dr. Ryan O´Shaughnessy
Senior
Research Associate in Skin Biology
Immunobiology
UCL Institute of Child Health
30 Guilford Street
London WC1N 1EH
UK
phone: +44 (0)207 905 2182
r.oshaughnessy@ich.ucl.ac.uk
Research
focus
-
The molecular mechanisms of barrier acquisition during development
-
Mechanisms of barrier disruption in skin disease (Eczema and Lamellar Ichthyosis), and viral infection (HPV)
Important publications
- Ben Jackson,
Stuart J. Brown, Ariel A. Avilion, Katherine Sully, O'Shaughnessy
RFL, Mark Murphy, Maria Ambrus, Michael L. Cleary, Carolyn Byrne.
TALE homeodomain proteins regulate body site-specific epidermal terminal
differentiation and skin barrier. J Cell Sci 2011; 124:1681-1690
- O'Shaughnessy
RFL, Choudhary I and Harper JI. Interleukin-1 alpha blockade prevents
hyperkeratosis in an in vitro model of lamellar ichthyosis -Human
Molecular Genetics 2010; 19(13): 2594-2605
- Byrne CR, Avilion
AA, O'Shaughnessy RFL, Welti JC and Hardman MJ. Whole-Mount Assays
for Gene Induction and Barrier Formation in the Developing Epidermis
- Methods in Molecular Biology 2010; 585 (271-86)
- O'Shaughnessy
RFL, Welti JC, Byrne C, AKT-Dependent PP2A activity is required for
epidermal barrier formation during late embryonic development. Development
2009. Sep, 136: 3423-3431
- O'Shaughnessy
RFL, Akgul B, Pfister H, Harwood C and Byrne CR. Cutaneous human papillomaviruses
downregulate Akt1 while Akt2 upregulation and activation associates
with tumours. Cancer Res. 2007 Sep 1; 67(17):1-9
- O'Shaughnessy
RFL, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C.
AKT-dependent HspB1 (Hsp27) Activity in Epidermal Differentiation.
J Biol Chem. 2007 Jun 8;282(23):17297-305
- O'Shaughnessy
RFL, Christiano AM. Inherited disorders of the skin in human and mouse:
from development to differentiation. Int J Dev Biol. 2004;48(2-3):171-9
- Jahoda CA, Kljuic
A, O'Shaughnessy RFL, Crossley N, Whitehouse CJ, Robinson M, Reynolds
AJ et al.,. The lanceolate hair rat phenotype results from a missense
mutation in a calcium coordinating site of the desmoglein 4 gene.
Genomics. 2004 May;83(5):747-56
- Kljuic A, Bazzi
H, Sundberg JP, Martinez-Mir A, O'Shaughnessy RFL, Mahoney MG et al.,.
Desmoglein 4 in hair follicle differentiation and epidermal adhesion:
evidence from inherited hypotrichosis and acquired pemphigus vulgaris.
Cell. 2003 Apr 18;113(2):249-60