Dr.
Sandrine Dubrac
Dr. Robert Gruber
Prof. Dr. Matthias Schmuth (presently at USCF)
Department
of Dermatology
Innsbruck Medical University
Anichstrasse 35
A-6020 Innsbruck, Austria
phone: +43-512-504-28589
fax: +43-512-504-22990
www.uibk.ac.at
We welcome patient / DNA referrals for filaggrin genotyping (ichthyosis
vulgaris, atopic dermatitis):
Please contact r.gruber@i-med.ac.at
Research
focus
-
Nuclear Hormone Receptors as Regulators of Cutaneous Homeostasis
-
Disease Models of Epidermal Differentiation and Cornification
Important publications
-
Gruber R, Janecke AR, Grabher D, Sandilands A, Fauth C, Schmuth M.
Evidence for genetic modifiers other than filaggrin mutations in X-linked ichthyosis. J Dermatol Sci. 2010 Jan28. [Epub ahead of print]
-
Dubrac S, Elentner A, Ebner S, Horejs-Hoeck J, Schmuth M. Modulation of
T lymphocyte function by the pregnane x receptor. J Immunol. 184:2949-57, 2010
-
Gruber R, Wilson NJ, Smith FJ, Grabher D, Steinwender L, Fritsch PO,
Schmuth M. Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations. Br J Dermatol. 161:1391-5, 2009
-
Elias PM, Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol. 9:437-46, 2009
-
Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg
JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol. 124:496-506, 506.e1-6, 2009
-
Elentner A, Finke D, Schmuth M, Chappaz S, Ebner S, Malissen B, Kissenpfennig A, Romani N, Dubrac S. Langerhans cells are critical in the development of atopic
dermatitis-like inflammation and symptoms in mice. J Cell Mol Med. 13:2658-72, 2009