Dr. Michel Simon, PhD

CNRS-UPS UMR5165
Différenciation épidermique et autoimmunité rhumatoïde
Hôpital Purpan
Place du Dr Baylac, TSA 40031
31059 Toulouse cedex 9
France

phone: (0)5 61 15 84 27
fax:      (0)5 61 49 90 36
msimon@udear.cnrs.fr

Research focus

• Molecular basis of hydration and cohesion of the Stratum Corneum. Physiopathology of the desquamation. Psoriasis pathogenesis
  
  
• Importance of deimination and peptidylarginine deiminases in epidermal differentiation and for hair follicles
  

Important publications

• Long-Range Enhancer Differentially Regulated by c-Jun and JunD Controls
  Peptidylarginine Deiminase-3 Gene in Keratinocytes. Adoue V, Chavanas S,
  Coudane F, Méchin MC, Caubet C, Ying S, Dong S, Duplan H, Charveron M,
  Takahara H, Serre G, Simon M. J Mol Biol. 2008 Oct 15. [Epub ahead of print]
  
  
• Long-range enhancer associated with chromatin looping allows AP-1 regulation
  of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
  Chavanas S, Adoue V, Méchin MC, Ying S, Dong S, Duplan H, Charveron M,
  Takahara H, Serre G, Simon M. PLoS ONE. 2008;3(10):e3408. Epub 2008 Oct 16
  
  
• Lamellar bodies of human epidermis: proteomics characterization by high
  throughput mass spectrometry and possible involvement of CLIP-170 in their
  trafficking/secretion. Raymond AA, Gonzalez de Peredo A, Stella A,
  Ishida-Yamamoto A, Bouyssie D, Serre G, Monsarrat B, Simon M. Mol Cell
  Proteomics. 2008 Nov;7(11):2151-75. Epub 2008 Jul 12
  
  
• Alterations in the desquamation-related proteolytic cleavage of
  corneodesmosin and other corneodesmosomal proteins in psoriatic lesional
  epidermis. Simon M, Tazi-Ahnini R, Jonca N, Caubet C, Cork MJ, Serre G. Br J
  Dermatol. 2008 Jul;159(1):77-85. Epub 2008 Jul 1
  
  
• Transcriptional regulation of peptidylarginine deiminase expression in human
  keratinocytes. Ying S, Dong S, Kawada A, Kojima T, Chavanas S, Méchin MC,
  Adoue V, Serre G, Simon M, Takahara H. J Dermatol Sci. 2008 Nov 10. [Epub
  ahead of print]
  
  
• M.-C. Méchin, M. Sebbag, J. Arnaud, R. Nachat, C. Foulquier, V. Adoue, F. Coudane, H. Duplan, A.-M. Schmitt, S. Chavanas, M. Guerrin, G. Serre and M. Simon. Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases. Intern. J. Cosmetic Sci. 2007, 29: 147-168
  
  
• A.-A. Raymond, M.-C. Méchin, R. Nachat, E. Toulza, R. Tazi-Ahnini, G. Serre, M. Simon. Nine procaspases are expressed in normal human epidermis, but only caspase-14 is fully processed.Br. J. Dermatol. 2007, 156 : 420-427
  
  
• Méchin M-C, Enji M, Nachat R, Chavanas S, Charveron M, Ishida-Yamamoto A, Serre G, Takahara H, and Simon M. The peptidylarginine deiminases expressed in human epidermis differ by their substrate specificities and sub-cellular locations. Cell. Mol. Life Sci. 62:1984-1995, 2005
  
  
• Nachat R, Méchin M-C, Takahara H, Chavanas S, Charveron M, Serre G, and Simon M. Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deiminarion of K1 and filaggrin. J. Invest. Dermatol. 124:384-393, 2005
  
  
• Caubet C, Jonca N, Brattsand M, Guerrin M, Bernard D, Schmidt R, Egelrud T, Simon M, and Serre G. Degradation of corneodesmosome components by two kallikreins SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J. Invest. Dermatol. 122:1235-1244, 2004
  
  
• Levy-Nissenbaum E, Betz R-C, Frydman M, Simon M, Lahat H, Bakhan T, Goldman B, Bygum A, Pierick M, Hillmer A-M, Jonca N, Toribio J, Kruse R, Dewald G, Cichon S, Kubisch C, Guerrin M, Serre G, Nöthen M-M, Pras E. Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin. Nature Genet. 34:151-153, 2003
  
  

 

to the top